ABSTRACT
Clinical and experimental data point to the participation of the neocerebellum and particularly of the dentate nucleus (DN) in the generation of limb movements. The purpose of the present contribution was to investigate the contribution of the DN to the specification of movement parameters and in the releasing of motor programs. This role was analyzed in baboons performing goal-directed responses. More precisely the effects of DN dysfunction on the latency of pointing movements, with variable amplitude or direction, were studied. Changes in reaction times, observed under different experimental conditions, are discussed in view of the role usually attributed to the neocerebellum in motor preparation and programming. The present data suggest a critical involvement of the DN in the processes preceding the triggering of limb movements, although the possible participation of the DN in controlling ongoing responses should also be considered.
