ABSTRACT

In recent years, the rehabilitation community has shown increasing interest in a therapeutic role for pharmacological interventions that might have beneficial effects on higher cerebral functions following traumatic brain injury (TBI). Advances in acute surgical trauma care, combined with increasingly sophisticated rehabilitative interventions, have led to improved patient treatment. However, uniformly satisfactory cognitive and behavioral outcomes for patients and families remain elusive. In an attempt to bring additional tools to bear on this problem, appropriate attention has begun to be directed toward pharmacotherapy. Major goals of a pharmacological approach in TBI patients include the following:

Amelioration of disturbances in psychological/behavioral function.

Enhancement of cognitive capabilities.

Promotion of neurological recovery.