ABSTRACT
Acetylcholine (ACh) is a neurotransmitter in various regions of the central nervous system (CNS), at ganglionic and postganglionic sites in the peripheral nervous system, and at the neuromuscular junction. In the periphery, transmission of ACh participates in the regulation of a host of autonomic functions, glandular and smooth muscle activity, as well as skeletal muscle contraction. In the central nervous system, the functions of ACh are not as clearly defined. At this level cholinergic neurons may serve in the control of movement, sleep, fluid intake, sexual behavior, reactions to stress, and other behaviors. The symptomatology of Huntington's and Alzheimer's disease appear to derive impetus from disruption of normal cholinergic function.
