ABSTRACT

Cardiovascular related diseases are the leading causes of death in western industrialized societies; and even in their nonlethal manifestations, these diseases produce immense economic, social, and psychological suffering. Despite decades of intense biomedical research, knowledge of the etiology of coronary heart disease (CHD) remains so limited that most new cases cannot be predicted from the best combination of the traditional risk factors of elevated levels of blood pressure, serum cholesterol, and smoking (Jenkins, 1976; Keys, Taylor, Blackburn, Brozek, Anderson, & Simonson, 1971).