Unless the Swiss Parliament adopts a new law on corporate due diligence, Swiss citizens will decide in 2020 whether to adopt or reject a partial revision of the Constitution of Switzerland that aims to introduce a provision on responsible business. According to the proposal, companies that are based in Switzerland are required to carry out appropriate human rights and environmental due diligence in Switzerland and abroad. The proposal also entails a provision for companies that makes them liable for the harm caused by companies under their control unless they can prove that they took all due care to avoid the harm. This contribution presents and assesses the content of the Swiss Popular Initiative on Responsible Business in light of the United Nations Guiding Principles on Business and Human Rights and the Organisation for Economic Cooperation and Development Guidelines for Multinational Enterprises. It also compares the Swiss popular initiative with the recently adopted French loi relative au devoir de vigilance and other recent legislative developments. It identifies a trend toward more precise liability provisions for corporate human rights abuses in international operations.