ABSTRACT
The treatment of low back pain is virtually a therapeutic conundrum. The pathology underlying low back pain can vary from varying grades of spondylitis or physical injury to conditions where there is little or no obvious joint pathology. Supraspinatus tendinitis is a common clinical problem encountered by family physicians. Ibuprofen has a long and well-established record of being a safe and effective therapy in a considerable range of chronic arthritic and non-arthritic states, and in treatment of acute pain, inflammatory and febrile states. In patients with alcoholic liver disease, ibuprofen kinetics have been shown to be within normal limits. Animal toxicity studies with ibuprofen have demonstrated that the principal toxicological effects are on the gastrointestinal tract, commonly in the form of gastric ulcers. The first clinical trials of ibuprofen in the treatment of arthritic conditions were performed in 1966 in patients probably with active rheumatoid disease.
