ABSTRACT
The rate of chemical reactions involving bond making, which correlates the stereochemistry of starting materials and products in terms of transition states and intermediates, is defined as dynamic stereochemistry. Chirality is of significant industrial importance in natural products, especially food taste, odor, and agrochemicals. In 1992, the United States Food and Drug Administration issued a guideline specifying that chiral drugs could be brought to the market only for their therapeutic use as active isomers and that each enantiomer of the drug should be studied separately for its pharmacological and metabolic pathways. Thin-layer chromatography techniques are a developing branch of separation and quantization of drugs both in pharmaceutical dosage forms and in biological materials. Drug–receptor interactions are stereoselective, that is, minor changes in the structure of a drug molecule can produce major changes in its pharmacological properties.
