ABSTRACT
It is well known that libido can have a significant impact as a “conditioner” for sexual function, and thus androgens may play an important role in both libido and the pathophysiology of erectile dysfunction (ED). In order to understand role of endocrine disruptors in ED, it is important to consider how endocrine system interacts with sexual function. Studies have shown an increased prevalence of ED, reduced libido, delays in achieving erection, orgasm, and prolonged latency time in the aged men, where hypogonadism is more frequent than in young men. Total testosterone is usually found to be normal in ED patients. Diabetes mellitus has been one of the most common cause of ED. Men with hyperprolactinemia tend to have decreased libido and have ED. Sickle cell anemia has been found to cause hypoandrogenism, due to testicular damage that may lead to ED. ED and gynecomastia are commonly encountered in chronic liver diseases.
