ABSTRACT
The relationship of obesity with the incidence of cardiovascular disease, and especially coronary heart disease, has been studied in a large number of cohort studies; little doubt remains that obesity is associated with other known cardiovascular risk factors, such as hypertension, lipid metabolism abnormalities, and diabetes mellitus. Early studies on the relationship between impaired fibrinolysis and obesity were performed with methods, such as the euglobulin clot lysis time or euglobulin lysis on fibrin plates, that simultaneously reflect the function of both fibrinolytic activators and inhibitors and are also influenced by other components of the hemostatic system, such as fibrinogen. Although the problem of the effect on fibrinolytic activity of dietary restriction and associated weight reduction is of great relevance, results to date have been scanty. The training-induced weight reduction correlated well with changes in plasminogen activator inhibitor activity.
