ABSTRACT
Nasal drug delivery is a versatile route of drug administration allowing systemic delivery of small and large molecules, treatment of local and systemic diseases, and noninvasive targeted central nervous system delivery. Drug delivery to the nasal cavity is complicated by several barriers, including the anatomical structure of the nasal cavity, variability in the nasal cavity anatomy between individuals, nasal mucociliary clearance, enzymatic activity of the nasal mucosa, and the effect of disease state on drug delivery and absorption. In Chapter 22, discussion of these barriers to nasal drug delivery is presented as well as a description of the fundamentals for analyzing and developing successful formulations and devices for delivering drugs by the nasal route.
