ABSTRACT

Having covered the basic methods and approaches to systems biology in the preceding chapter, it is appropriate to focus on the areas of research that are currently active to extend our capabilities. The presentation begins on a small scale-how to perform single-cell microarray assays-then scales up to high-throughput methods of protein assay, jumps to ways to integrate low-level data with higher-level abstractions of biological process, addresses the core question of how to make the association between low-level genetic data and high-level phenotypes, and concludes with a review of molecular-level imaging and the systems biology approach.