ABSTRACT
The use of pharmacokinetic principles has become widespread in the pharmaceutical industry, primarily because of their utility in relating efficacy and toxicity to drug concentrations in plasma or some other appropriate body compartment. In general, pharmacokinetics is the process of absorption, distribution, and excretion of a drug. Excretion is usually coupled with metabolism, which typically converts drug to a more water-soluble form, more amenable to excretion. Most of the pharmacokinetic literature deals with systemically administered drugs that reach their pharmacological target by way of the blood following oral or parenteral administration.
