ABSTRACT
This chapter examines methods of assessing the genetic component of obesity. The data suggest that genetics can make a substantial contribution to obesity through actions modifying function in both the hypothalamus and adipose tissue, supplemented by substantial effects on genetically controlled inter-individual differences in habitual physical activity, as well as environmental influences (including a family’s diet and lifestyle, and personal choices with regard to habitual physical activity and dietary patterns). Although some genes predispose to the accumulation of body fat, they also seem to make it easier to shed the excess of fat when participating in an appropriate weight-loss programme. A supposed genetic predisposition to obesity thus should not serve as a reason for allowing a person to remain excessively fat.
