Health Technology Assessment (HTA) is an emerging approach to develop information on the impact of new and existing health care interventions, promote clinical decision making based on evidence, and inform investment choices. This chapter addresses the robustness of the findings and recommendations of HTA to change clinical practice and improve the quality of care. It details the context and sampling frame for the study and the study's design and method. The chapter discusses the implications of findings for clinical practice development and research. It presents the results of analysis addressing the extent to which health technology assessments produce recommendations that can and should affect clinical practice. The chapter also describes the general characteristics of the sixty-four health technologies examined in sample. It explores the robustness of evidence demonstrating the effectiveness, maturity and cost benefit of these interventions, products, services and packages of care used in daily practice.