ABSTRACT
This chapter highlights the human endometrium in some context in the dawn of the age of precision medicine. It describes the complexities of human endometrium in clinical practice and women's well-being and in research in an effort to advance women's reproductive health beyond empirical therapies, unpredictable endometrial responses, and unpredictable prognoses for contraception, fertility, pregnancy outcomes, and endometrial morbidities. The endometrium and other components of female reproductive tract are highly vulnerable to endocrine-disrupting chemicals (EDC) exposure in utero, with potentially long-lasting effects on reproductive potential in adulthood that should be considered in preventive health strategies and optimizing reproductive health in the long term. Precision medicine is an emerging field for disease prevention, classification, diagnosis, and targeted treatment based on individual characteristics, including genetic variations, environmental exposures, lifestyle, and experiences across the life span. Endometrium comprises several cell types, including glandular epithelium, luminal epithelium, stromal fibroblasts, vascular smooth muscle, and endothelium; an array of immune cells; and stem or progenitor cells.
