ABSTRACT
The wide and clinically well-accepted usage of emulsions for parenteral nutrition has raised the possibility of using the internal oil core of the oil-in-water emulsion for solubilizing water-insoluble drugs. A major limitation of the emulsion delivery systems is that they cannot be adapted to the delivery of water-soluble drugs as no advantage over a simple aqueous solution could be foreseen. The main therapeutic applications of submicron emulsions should be sought in emulsion formulations designed for parenteral administration of poorly water soluble drugs. Enormous activity in drug delivery and targeting research using submicron emulsions as carriers of poorly water soluble drugs. In most cases the introduction of a drug within such an emulsion introduced a marked physical instability resulting in phase separation of the emulsion in a relatively short period of time.
