This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book proceeds through a problematizing re-description of the history of political science (PS) from the point of view of power-knowledge dynamics and identifies the conceptual and institutional components that constitute the dominant disciplinary discourse. It makes use of in-depth interviews with Uruguayan political scientists. Self-reflection transforms analysis is an auto-ethnographic account that raises the book’s temperature to the point of burning, threatening to melt the boundaries between story, subject, and object. The book shows how the way PS’ story is told by old and new mainstreams exercises epistemic violence by naturalizing positivism, liberalism, and, by extension, capitalism. It explores a range of critical theories that tackle the political dimension of knowledge production.