The experience of Tunisia differentiates the experiences of the Muslim Brotherhood across the Middle East where the ruling regimes have been more resilient and enduring in the face of revolt, protest, rebellion, and revolution. This chapter analyzes the extent to which Ennahda can pursue its Islamist agenda in a state traditionally recognized as one of the most secular in the Middle East. It also examines the challenge that has faced the organization and its potential for emulation, in terms of the role of the Muslim Brotherhood in other political transitions within the region and power holding in the wake of the Arab Spring, known locally as the Jasmine Revolution. The future for the Muslim Brotherhood in Tunisia as envisioned by Ennahda, however, is far from assured in terms of driving through the type of inclusion of Islam into state and politics that leaders such as Rachid Ghannouchi had long envisioned.