ABSTRACT
The vitreous humor is a viscous fluid occupying the space between the lens and retina of the eye. A number of diseases that can affect the vitreous or the surrounding retina can be treated by administration of various therapeutic drugs. Due to physiological barriers within the eye that prevent drug in the systemic circulation from entering the vitreous, the most common method of treating diseases affecting the vitreous or retina is a direct intravitreal injection of drug (1). Many of the drugs used to treat vitreous and retinal disorders have a narrow concentration range in which they are effective, and they may be toxic at higher concentrations (2-6). Therefore, knowledge of the drug distribution following intravitreal administration is important if the disease is to be properly treated and damage to tissues by high concentrations of drug is to be avoided.
