Meaning pervades research and everyday experience alike, surrounding, enabling, guiding them and making them worthwhile, often unseen. This chapter is about meaning—about meaning as such, as a cross-field philosophical notion rather than meanings from a psychological, linguistic, sociological, theological or any other perspective. It offers an overview of how philosophy has addressed meaning and sketches out Herman Dooyeweerd’s understanding of meaning. Not only can Dooyeweerd’s view meet various philosophical challenges, but it is particularly helpful in various areas of research, to stimulate fresh perspectives. To Dooyeweerd, reality is meaning, indeed, almost a synonym for reality. The chapter strengthens the notion of aspects, as modalities or spheres of meaningfulness and corresponding law. It discusses some implications for research application, activity and content. For example, that meaningfulness is a unifying context for all three implies that ontology, epistemology and axiology are no longer separate issues.