Decontamination of the environment is a very important part of the control of Microsporum canis feline dermatophytosis. However, there is a very limited number of chemical agents that can reach a complete effectiveness against M. canis environmental contaminants. In addition, results of research studies often show discrepancies and differences, and the efficacy of many products appears to be controversial, since it was not always confirmed in the different experimental trials. The purpose of this chapter is to provide an overview of compounds that show many similarities among the different studies, and that can be currently proposed for the environmental control of M. canis infections in cats. Mainly, these included chlorine-based compounds, enilconazole, and lime sulphur. The practical applications that have proved successful are also reviewed.