ABSTRACT
In 1965 H. A. Dymsza et al. reported the establishment of a GN microflora consisting of four species “of predominating microorganisms of human intestinal origin” isolated from young males, in young Germfree (GF) rats. R. W. Schaedler et al., working in Dubos’ laboratory at Rockefeller University, reported the establishment of a stable “hexaflora” in ex-GF mice, an ecosystem comprising mouse intestine-derived Lactobacillus brevis, Enterococcus faecalis, Staphylococcus epidermidis, Bacteroides fragilis var. vulgatus, Enterobacter aerogenes, and a Fusibacterium sp. Monoassociation has been used by S. Sasaki and co-workers to study performance of a number of microorganisms in CD-1 mice as a basis for the formation of an “artificial” but defined microflora. The incidence of human disease caused by Candida albicans has increased steadily, pointing to the need for a reliable model for candidiasis that mimics the systemic disease in humans, and could suggest means to control its pathogenicity.
