ABSTRACT
Other common trade names: Cardigox; Digacin; Digoxine; Eudigox; Lanicor; Lenoxin; NovoDigoxin Indications: Congestive heart failure, atrial fibrillation Category: Antiarrhythmic; Cardiac glycoside; Inotropic Half-life: 36-48 hours Clinically important, potentially hazardous interactions with: alprazolam, amiodarone, amphotericin B, arbutamine, bendroflumethiazide, benzthiazide, bumetanide, chlorothiazide, chlorthalidone, cholestyramine, clarithromycin, cyclosporine, cyclothiazide, demeclocycline, devil’s claw, doxycycline, erythromycin, esomeprazole, ethacrynic acid, furosemide, ginseng, hawthorn fruit, leaf, flower extract, hydrochlorothiazide, hydroflumethiazide, indapamide, licorice, mepenzolate, methyclothiazide, metolazone, minocycline, mistletoe, oxytetracycline, polythiazide, propafenone, propantheline, quinethazone, quinidine, rifampin, sarsaparilla, senna, siberian ginseng, st john’s wort, telithromycin, teriparatide, tetracycline, trichlormethiazide, verapamil
Reactions
Skin Angioedema Bullous eruption [1] Diaphoresis [1] Exanthems (1.6%) [3] Pruritus [1] Psoriasis [1] Purpura [1] Rash (sic) Urticaria [2] Vasculitis [1]
Hair Hair – alopecia
Nails Nails – loss (finger-and toenails)
Eyes Dyschromatopsia (green) [1]
Other Gynecomastia [1] Headache
Trade names: Cardizem (Biovail); Cartia-XT; Dilacor XR (Watson); Diltia-XT; Teczem (SanofiAventis); Tiazac (Forest) Other common trade names: Alti-Diltiazem; Britiazem; Calcicard; Deltazen; Dilrene; Diltahexal; Nu-Diltiaz; Presoken; Tiamate; Tilazem; Tildiem Indications: Angina, essential hypertension Category: Antianginal; Antiarrhythmic; Calcium channel blocker Half-life: 5-8 hours (for extended-release capsules) Clinically important, potentially hazardous interactions with: alfuzosin, amiodarone, aprepitant, carbamazepine, corticosteroids, cyclosporine, epirubicin, erythromycin, mistletoe, simvastatin
Teczem is diltiazem and enalapril
Acne [1] Acute generalized exanthematous pustulosis (AGEP) [12]
Adverse effects (sic) [1] Angioedema [2] Capillaritis (Schamberg’s) [1] Dermatitis Diaphoresis [2] Edema (1-10%) [4] Erythema [2] Erythema multiforme (1-31%) [9] Exanthems [16] Exfoliative dermatitis (<1%) [6] Flushing (1-10%) [5] Hyperkeratosis (feet) [1] Lichenoid eruption (photosensitive) [2] Lupus erythematosus [5] Palmar-plantar desquamation [1] Peripheral edema (5-8%) [2] Petechiae (<1%) Photosensitivity (<1%) [11] Pigmentation [4] Pruritus (<1%) [7] Psoriasis [3] Purpura (<1%) [3] Pustular psoriasis [1] Pustules [2] Rash (sic) (1.3%) [3] Side effects (sic) [2] Stevens-Johnson syndrome [4] Subcorneal pustular dermatosis [2] Thickening [2] Toxic dermatitis [1]
Toxic erythema [2] Ulcerations of legs [2] Urticaria (<1%) [4] Vasculitis (<1%) [6]
Hair Hair – alopecia (<1%) [2] Hair – hirsutism [1]
Nails Nails – dystrophy [1]
Eyes Periorbital edema [1]
Hematopoietic Ecchymoses (<1%)
Other Dysgeusia (<1%) [1] Erythromelalgia [1] Fever [1] Gingival hypertrophy (21%) [6] Gynecomastia [1] Headache Hypersensitivity [1] Lymphadenopathy [1] Myoclonus [1] Parageusia (<1%) Paresthesias (<1%) [1] Parkinsonism [2] Pseudolymphoma [1] Rhabdomyolysis [3] Tinnitus Tremor (<1%) Xerostomia (<1%) [2]
