PRAVASTATIN

Other common trade names: Elisor; Lipostat; Pravasin; Pravasine; Selectin; Selektine; Selipran Indications: Hypercholesterolemia Category: Antihyperlipidemic; HMG-CoA reductase inhibitor Half-life: ~2-3 hours Clinically important, potentially hazardous interactions with: azithromycin, clarithromycin, cyclosporine, erythromycin, gemfibrozil, imatinib

Reactions

Skin Allergic reactions (sic) [1] Angioedema Dermatomyositis [1] Eczema (generalized) [1] Erythema multiforme Exanthems Flu-like syndrome Flushing [1] Lichenoid eruption [2] Lupus erythematosus Neuroleptic malignant syndrome [1] Photosensitivity Pruritus [2] Purpura Rash (sic) (1-10%) [7] Stevens-Johnson syndrome Toxic epidermal necrolysis Urticaria

Vasculitis

Hair Hair – alopecia [1] Hair – broken-off patches of scalp hair (greenish) [1]

Other Anaphylactoid reactions Dysgeusia (<1%) Gynecomastia [1] Headache Hypersensitivity Myalgia (2.7%) [6] Myositis [1] Paresthesias Polymyositis [1] Porphyria cutanea tarda [1] Rhabdomyolysis [9] Stomatitis

Trade names: Minipress (Pfizer); Minizide (Pfizer) Other common trade names: Alti-Prazosin; Apo-Prazo; Duramipress; Eurex; Hypovase; Nu-Prazo; Peripress; Pratisol; Pressin Indications: Hypertension Category: Alpha-adrenoceptor blocker; Antihypertensive Half-life: 2-4 hours Clinically important, potentially hazardous interactions with: epinephrine

Minizide is prazosin and polythiazide

Angioedema [1] Diaphoresis (<1%) [2] Edema (1-4%) [1] Exanthems (1-5%) [1] Lichen planus (<1%) Lichenoid eruption Lupus erythematosus [2] Pruritus (<1%) [1] Rash (sic) (1-4%) [2] Urticaria [1]

Hair – alopecia (<1%)

Other Anaphylactoid reactions [1] Headache Myalgia [1] Paresthesias (<1%) Priapism (<1%) [2] Tinnitus Xerostomia (1-4%) [3]

Trade names: Procan (Pfizer); Procanbid (Pfizer); Pronestyl; Rhythmin Other common trade names: Amisalen; Biocoryl; Procan SR; Promine; Ritmocamid Indications: Ventricular arrhythmias Category: Antiarrhythmic class I A Half-life: 2.5-4.5 hours Clinically important, potentially hazardous interactions with: abarelix, arsenic, ciprofloxacin, enoxacin, gatifloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin

Reactions

Skin Angioedema (<1%) [1] Chills (<1%) Dermatitis (6%) [1] Eczema Exanthems (1-8%) [5] Flushing (<1%) Lichen planus [1] Lupus erythematosus (>10%) [169] Pruritus (<1%) Purpura [3] Rash (sic) (<1%)

Sjøgren’s syndrome [1] Urticaria (1-5%) [1] Vasculitis [4]

Other Dysgeusia (3-4%) (bitter taste) [1] Myalgia (<1%) [2] Oral mucosal eruption (2%) [1] Pseudolymphoma [1] Torsades de pointes [1] Tremor (<1%)