ABSTRACT
Description: LeukoScan consists of the antigen-binding Fab’ fragments of the monoclonal antibody sulesomab. Sulesomab displays binding affinity for the surface granulocyte nonspecific cross-reacting antigen (NCA90), present on the surface of granulocytes, and also for the carcinoembryonic antigen (CEA). It is produced in mice by ascites technology and, after processing, is provided in a lyophilized form (0.31 mg/vial). Before administration as an intravenous injection, LeukoScan is conjugated with the radioactive technetium-99m isotope (99mTc, obtained separately) for immunoscintigraphy.
