ABSTRACT
Description: Orthoclone OKT-3 is an intact murine monoclonal antibody produced by classical hybridoma technology. The antibody binds specifically to a 20-kDa surface glycoprotein found exclusively on the surface of mature T lymphocytes and medullary thymocytes. This surface glycoprotein is also known as the CD-3 receptor, and binding of antibody hinders cellular functioning by interfering with cell-mediated immune responses. Particularly affected is the functioning of cytotoxic T lymphocytes that are involved in the recognition and destruction of foreign antigens, such as those involved in mediating acute allograft rejection. Orthoclone OKT-3, which was the first monoclonal antibody to be approved for in υiυo use, is generally supplied in packages of five ampules. Each 5-ml ampule contains 5 mg of active ingredient.
