ABSTRACT
The skin has long been used as a site for drug administration of therapeutic
agents for localized pharmacological actions (Kastrip and Boyd, 1983). Drug
delivery through the skin for systemic effects, though limited, is a well-
established branch of pharmaceutics. The stratum corneum, the outermost layer
of the skin offers excellent barrier properties to applied substances thus limiting
the number of drug candidates for passive transdermal delivery to usually small,
potent and lipophilic compounds. Physical and chemical techniques have been
used to improve the permeability of the skin to applied substances. Dermal
iontophoresis is one of such physical techniques.
