ABSTRACT
Cloning is commonplace and the human genome is elucidated at a rapid pace.
We have established a plausible pathogenesis and begun to make significant
progress in design and execution of rational treatments for many diseases of the
skin. Exciting progress in development of drugs that have immunomodulatory
effects on psoriasis has vastly expanded our understanding of the disease itself
and clarified many complex mechanisms by which the immune system can be
regulated. The question of how drugs work and by what mechanisms they
produce toxicity has never been more relevant or capable of solution.
