ABSTRACT
Among the dermatotoxicologic community working on immune skin effects
manifested as allergic contact dermatitis, the proven effective strategy has been
to develop and apply animal assays for identification of chemical xenobiotics
with allergenic potential and to assess the sensitization hazard potential of these
environmental contactants for human beings. Since 1935 (Landsteiner and
Jacobs, 1935) the guinea pig has represented the reference animal model.
