ABSTRACT
Single-dose first-or second-generation
Cefuroxime: single dose pre-incision
Thoracic (noncardiac)
Gram-negative bacilli
cephalosporin or vancomycina
Neuro S. aureus, S. epidermidis
Single-dose firstgeneration
Cefazolin: single dose pre-incision
Orthopaedic Less likely to have Gramnegative
cephalosporin or vancomycina
Vascular, including amputation
organisms
Traumatic, without perforation of viscus
Gastrointestinal
• Upper tract (oesophagus, stomach, small bowel)
Enteric Gramnegative bacilli, Gram-positive cocci
High risk (advanced age, morbid obesity, oesophageal obstruction, or reduced gastric motility) defines need for expanded coverage
Low risk: cefazolin High risk: cefuroxime, cefoxitin, Cefotetan, or ampicillin+sulbactam
• Biliary tract Enteric Gramnegative bacilli, clostridia, Enterococcus sp.
