ABSTRACT

Introduction ..............................................................................................................1 Proposal 1. Identification of New Drug-Targeting Proteins and Isolation

of Novel Genes ...................................................................................2 Proposal 2. Exploration of Functions or Roles for the Expression of a Gene

Targeted by a New Drug ....................................................................4 Proposal 3. Verification of Potential Function of a Specific Gene by the Gene

Knockout Approach ............................................................................4 Proposal 4. Identification of the Functional Domain of a Protein by Site-Specific

Mutagenesis ........................................................................................4 Proposal 5. Identification of Toxicant-Binding Proteins and Isolation

of a Novel Gene Related to the Toxicant and Heart Hypertrophy Using an Animal Model .....................................................................4

Proposal 6. Rescue of an Immune-Deficient System via Gene Therapy .............8 Proposal 7. Discovery of IAA-or GA3-Binding Proteins and Isolation