ABSTRACT

Mushrooms have long been considered to have medicinal value. The early herbalists were more interested in the medicinal properties of mushrooms than in their basic value as a source of food. Humankind has constantly searched for new substances that can improve biological functions and thereby make people fitter and healthier. Recently, Western society has placed a great emphasis on plants, herbs, and foods as sources of these health enhancers. About 3.5 billion people worldwide, well over half of the world’s population, rely on plant-based medicines and dietary supplements for their primary health care. These products have variously been called vitamins, dietary supplements, phytochemicals, nutraceuticals, and nutriceuticals. Dietary supplements 81 are ingredients extracted from foods, herbs, plants, and fungal species that are not used as a regular food but which boost the immune system or otherwise help maintain health. Phytochemical (phytonutrient) is a more recent evolution of the term that emphasizes the plant source of such protective disease-preventing compounds. Nutraceuticals, proposed by DeFelice in 1979 and quoted by Brower in 1988, 3 are foods that provide medical or health benefits, including the prevention and treatment of disease. The term nutraceutical has been redefined by Zeise1 81 as a diet supplement that delivers a concentrated form of a presumed bioactive agent from a food at dosage levels exceeding those that could be obtained from normal food. Nutraceuticals are present in a nonfood matrix and are used to enhance health. A mushroom nutriceutical 6 is a refined and partially defined extract from either the mycelium or the fruiting body of a mushroom, which is consumed in the form of capsules or tablets as a dietary supplement (not in the form of a food) and which has potential therapeutic application. During the past decade, there has been a major expansion in the industries involved in providing these substances, especially in the United States. In 1990, U.S. dietary supplement sales were valued at U.S. $3.3 billion; in 1992, U.S. $3.7 billion; in 1994, U.S. $5.0 billion; in 1996, U.S. $6.5 billion; in 1998, U.S. $12.0 billion; and in the year 2000, it was estimated to have reached U.S. $14.0 billion. 81