ABSTRACT
Memapsin 2 (BACE, ASP-2) is the membrane-anchored aspartic protease that processes APP at the
β
-secretase site.
The resulting C terminal fragment, C99, is further processed by
γ
-secretase to produce amyloid-
β
(A
β
) peptide.
Memapsin 2 (BACE, ASP-2) is the membrane-anchored aspartic protease that processes APP at the
β
-secretase site.
The resulting C terminal fragment, C99, is further processed by
γ
-secretase to produce amyloid-
β
(A
β
) peptide.