ABSTRACT
While the transmission of electrical signals across neuronal networks is a fundamental aspect of the operation of nervous systems, and this feature has traditionally been the main focus of computational neuroscience [10, 23], neurochemistry adds many dimensions to the picture. For instance, it is now recognised that nitric oxide (NO) is a novel kind of neurotransmitter that acts, through diffusion, over volumes that potentially contain many neurons and can facilitate signalling between neurons that are not synaptically connected [14, 46, 47]. This chapter aims to demonstrate that 1-58488-362-6/04/$0.00+$ 1.50
computational and mathematical modelling have an important role to play in trying to understand this particularly interesting mode of signalling.
