ABSTRACT
The carboxyphosphonates are the oldest and the most popular functionalized phosphonates. They are precursors of several reagents often used in organic synthesis such as diethyl 1-(hydroxycarbonyl)methylphosphonate, dialkyl 1-(alkoxycarbonyl)vinylphosphonates, and dialkyl 1-(alkoxycarbonyl)-1-diazomethylphosphonates. The are known for their valuable role in organic synthesis and in the recent development of the chemistry of Foscarnet and
ω
-amino-
ω
-(hydroxycarbonyl)alkylphosphonic acids. This chapter deals with their preparations and transformations.
