ABSTRACT
The popularity of epoxyphosphonates emanates from their simplicity, ease of access, and reactivity. The discovery of the antibiotic fosfomycin
[(1
R
,2
S
) (
−
)-1,2-epoxypropylphosphonic acid] in 1969 generated interest in the chemistry of 1,2-epoxyalkylphosphonates and higher homologues and gave rise to a large number of synthetic preparations. It has also given a biochemical significance to 1,2epoxyalkylphosphonates and their derivatives. The fosfomycin phenomenon has largely contributed to the interest in and development of this topic.
