ABSTRACT
We have now examined what distinguishes experimental design problems involving mixtures and applied the simplex lattice and centroid designs to explore responses over the whole of the possible factor space. As we said earlier, it is hardly realistic to expect all components to be allowed to vary from zero to one hundred percent in a real system. That this should be so for solid pharmaceutical dosage formulation is especially evident - each component of a solid dosage form has its own function,
and it will only fulfill that function within a limited concentration range. It is pointless attempting to study all possible combinations of the proportions of the components when we already know that many of these, probably the vast majority, are excluded.
