ABSTRACT
The most common clinically significant response to the subcutaneous or intramuscular administration of polyvinylpyrrolidone (PVP) is the cutaneous storage syndrome. In addition to the reports on the cutaneous effects discussed previously, there have been numerous other reports confirming both the clinical and histological manifestations of this syndrome. The patient suffered abdominal pains and other symptoms which led to a possible diagnosis of gastric or appendicular perforation. During surgery, a nodular lesion of the greater omentum was discovered which initially was considered to be a tumor. Malignancy was suspected because of its size, the large area of necrosis and the deep infiltration into the musculature. Subsequently, PVP was histochemically demonstrated to be present in the lesion. Injections into tissues with low blood circulation or muscles with limited mass will delay removal of the polymer. High molecular weight compounds such as PVP depend primarily on the lymphatic system for removal from intramuscular injection sites.
