ABSTRACT
The rabbit is the primary animal model used to investigate the teratogenic potential of new chemical entities. Thus, it is important to understand the disposition characteristics of the compound in this species. Additionally, rabbits are commonly employed in the evaluation of topical dosage forms such as those intended for the skin and eyes. As a laboratory animal for conducting ADME studies, the rabbit has certain distinct advantages in that it is relatively inexpensive and readily obtainable. Using proper restrainers, doses can be easily administered and blood samples collected. However, it should be noted that rabbits are more prone to contracting infectious diseases than other common laboratory species such as the rat and the dog. Also, the animal must be carefully handled to avoid fatal spinal injuries. Intravenous, subcutaneous, and intramuscular administration are the most commonly employed parenteral routes in the rabbit. Subcutaneous doses are administered using a syringe and a 21 G needle.
