ABSTRACT
The monkey is generally considered a good animal model for man in drug metabolism studies. Dosage forms intended for human use can readily be administered to the monkey. Monkeys also require special housing facilities and well-trained personnel for dosing and sample collection. Usually, at least two technicians are needed to control the animal during the experiment. The animal can be further restrained by using a pole with a hook at one end. After one technician has passed the hook through the monkey's neck collar, a second technician opens the front door slightly, firmly grasps a leg and extends it outside the cage. The leg is rotated until the saphenous or cephalic vein is visible. The blood is then collected as previously described. The front door of the cage is subsequently closed, the restraining hook released from the neck collar, and the sliding partition pushed back into its original position, freeing the monkey.
