ABSTRACT

This conclusion presents some closing thoughts on the key concepts discussed in the preceding chapters of this book. The book introduces the reader to polyurethane chemistry and solid state properties, their biological interactions and reviewed their performance in medical devices. It discusses the properties of polyurethanes are partially determined by the reagents selected for synthesis from the large range of possible precursors. Traditionally, biomaterials were employed to perform singular, biologically inert roles, such as to provide a conduit for blood flow, or as membranes for solute transport. Biomaterials potentially can be used as synthetic substrates for cell, tissue and organ engineering, helping the body to heal, or promoting regeneration of tissues, thus restoring physiological function. The field of biomaterials still lacks a battery of short term tests that can adequately predict the chronic biocompatibility of a device.