ABSTRACT

A successful model will allow considerable consolidation of the collected data. Mathematical modeling of experimental data can be an excellent method of exploring the mechanisms involved in the process under investigation. Analysis of the experimental data can lead to an empirical representation. By going through the process of considering a group of models and selecting a best model, exploration of basic mechanisms becomes possible and may be necessary. The analyst may be confronted with a large amount of data that needs to be understood. Thus modeling the data should give a useful insight into the mechanisms involved. An extension of this mathematical model can be used to calculate plasma concentrations after repeated doses. Concentration versus time data from a number of patients was modeled using a one-compartment pharmacokinetic model. Finally, successful determination of a good model and model parameters allows the prediction of results.