ABSTRACT
Vitamin C is used as a generic term for all compounds qualitatively exhibiting the biological properties of ascorbic acid. A deficiency of vitamin C leads to scurvy. Scurvy is characterized by hemorrhagic disorders such as petechiae and ecchymoses. Scurvy may be associated with loosening of the teeth, gingivitis, and anemia. In vitamin C deficiency, underhydroxylated collagen is formed. This defective collegen is subject to intracellular degradation. The extensive consumption of vitamin C has been stimulated by claims of various benefits derived from its use. The measurement of the ascorbic acid concentrations in whole blood or red blood cells appeared to provide no advantage over plasma ascorbic acid measurements for evaluating vitamin C status. In comparison with measurements of ascorbic acid in leucocytes, red blood cells, or whole blood, plasma ascorbic acid analysis remains the most feasible procedure for evaluating vitamin C nutritional status in individuals or population groups.
