ABSTRACT
Sequence relationships are usually not restricted to those between two sequences. Rather, they extend to relatedness among a family of sequences. The situation then is that experimentalists produced a gene sequence of approximately 6500 bps in length, which corresponds to an amino acid sequence of 1480 residues, the defective gene has a deletion of 3 bps that results in the deletion of a Phe residue in the amino acid sequence. Weighted-average sequences and, in particular, profile analyses proceed from a given multiple alignment to produce a sequence capturing the statistical details of the multiple alignment. The weighted-average sequence can then be used to discover more sequences that belong to the multiple alignment. Instead of using weighted-average sequences and profiles to discover new sequences, in this section we turn these ideas around and ask if a weighted-average sequence can be used to improve the multiple alignment from which it was derived.
