ABSTRACT
Effective control of chemo and steric selectivity of a chemical reaction lies in our ability to manipulate nano-environment of active sites. Due to difficulty in manipulating the active site on the nanoscale and lack of fundamental nderstanding of the reaction mechanism, development of chemo-and stereoselective catalysts has relied heavily upon empirical studies. One successful xample of fine-tuning steric environment of the active site is the use of chiral diphosphite ligands to control the selectivity of styrene hydroformylation on Rh omplex catalysts (1-3).
