The term ‘‘melt extrusion’’ implies the processing of polymeric materials at

temperatures above their glass transition temperature (Tg) in order to effect molecular-level mixing of active compounds and thermoplastic binders and/or

polymers (1). These processes are increasingly being performed on twin-screw

extruders as a result of their superior mixing capabilities and narrow residence

time distribution (2,3). A narrow residence time distribution is critical when

processing thermally sensitive active compounds.