ABSTRACT

When is an active molecule a good drug? Companies are developing new

screening tools to help them select druglike candidates early in the drug

discovery process. Determining an active compound’s ‘‘drugability’’ is a

bottleneck that can involve hundreds of tests to determine bioavailability

and toxicity (alone and in combination with other drugs); this comprises a set

of characteristics known as administration distribution metabolism excretion

toxicology (ADMET). However, one of these aspects, namely the improve-

ment of the solubility, dissolution rate, and absorption properties of poorly

water-soluble drugs, remains a challenging aspect in the development of

pharmaceutical products.