ABSTRACT
When is an active molecule a good drug? Companies are developing new
screening tools to help them select druglike candidates early in the drug
discovery process. Determining an active compound’s ‘‘drugability’’ is a
bottleneck that can involve hundreds of tests to determine bioavailability
and toxicity (alone and in combination with other drugs); this comprises a set
of characteristics known as administration distribution metabolism excretion
toxicology (ADMET). However, one of these aspects, namely the improve-
ment of the solubility, dissolution rate, and absorption properties of poorly
water-soluble drugs, remains a challenging aspect in the development of
pharmaceutical products.
