ABSTRACT
The term granulation, broadly speaking, refers to the process of particle
formation via agglomeration or size enlargement. As described in Perry’s
Chemical Engineers’ Handbook (1), it is a process of size enlargement where
small particles are clustered into larger, permanent aggregates in which the
original particles can still be identified. The granulation process has been known and used by mankind since prehistorical times. For instance, mortar
and pestle were used to formulate medicinal agents into solid dosage forms for
the treatment of ailments. A more descriptive definition of granulation (2) would be ‘‘the buildup of clusters from powder or powder/binder mixtures to
produce a free flowing, cohesive material that can be further processed by compression or encapsulation.’’
