The term granulation, broadly speaking, refers to the process of particle

formation via agglomeration or size enlargement. As described in Perry’s

Chemical Engineers’ Handbook (1), it is a process of size enlargement where

small particles are clustered into larger, permanent aggregates in which the

original particles can still be identified. The granulation process has been known and used by mankind since prehistorical times. For instance, mortar

and pestle were used to formulate medicinal agents into solid dosage forms for

the treatment of ailments. A more descriptive definition of granulation (2) would be ‘‘the buildup of clusters from powder or powder/binder mixtures to

produce a free flowing, cohesive material that can be further processed by compression or encapsulation.’’