Pharmaceutical class extruders are evolving as continuous processing devices

to mix drugs with carriers for solid dosage forms and transdermal films, as well as to produce wet granulations. In melt extrusion, which has been used

for many years in the plastics industry, the carrier is melted and mixed with

an active ingredient, devolatilized and pumped through a die. In contrast, wet

granulation refers to the process of fine powdered materials being mixed with liquids to impart morphological and other specific characteristics to facilitate the production and the performance of tablets and other solid

dosage forms. The focus of the discussion will be primarily aimed at melt

extrusion, the more common application and, to a lesser extent, at the wet

granulation process.