ABSTRACT
I. INTRODUCTION The first example of enantioselective interaction between a chiral guest molecule and cyclodextrin (CD) was described 50 years ago (1). Today it is hard to imagine separation science without the methods based on the enantioselective affinity interactions between chiral analytes and cyclodextrins. Enantioseparations by gas chromatography (GC), high-performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), and capillary electrochromatography (CEC) are based largely on these interactions. In addition, enantioselective drugcyclodextrin interactions are used in various spectrometric (UV, NMR, MS, etc.) and electrochemical techniques, and they may also be applied in pharmaceutical formulations for achieving an enantioselective transport, release, etc. of chiral drugs.
